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公司新闻/正文

优宁维之HTRF Epigenetic产品介绍

863 人阅读发布时间:2014-04-11 13:05

 
新闻图片1   新闻图片2
60万种抗体
最专业、最全面的抗体供应商
最专业、最全面的流式试剂供应商
最专业、最全面的免疫组化供应商
免费服务电话:4008-168-068 Email:info@univ-bio.com

新闻图片3


Epigenetics Introduction

     C.H. Waddington coined the term epigenetics in 1942, to explain how genes might interact with their surroundings to produce a phenotype. Changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence.

      Chromatin remodeling – changes in packaging of DNA & proteins that control access to DNA by the regulatory transcription machinery proteins and thus control gene expression.

   ·Modifications to DNA &/or proteins cause chromatin remodeling
   ·Factors that influence chromatin remodeling:

 

-  Development stage
-  Aging
-  Diet
-  Disease
-  Environmental chemicals
-  Drugs

 

Epigenetic Modifications
· DNA methylation
· Histone modifications
· Small & non-coding RNA

新闻图片4

The Histone modification landscape  
新闻图片5 新闻图片6


Epigenetic Researchers Are Currently Using TR-FRET (HTRF)

新闻图片7

HTRF Epigenetic Product Offering

  ·Toolbox(Reliable&Flexible)
  ·Companion Products
  ·Custom Services

HTRF Validated Assays

HMT/HDMT Assay Scheme

新闻图片8

新闻图片9

HTRF products for Biochemical Assays
Histone Modification Location
Enzymatic Typ
Enzymes
Reactions
Antibody
H3K4
HMT
SET7/9
Me0 to Me1
 
anti-H3K4me1-K
 
HDM
LSD1 Complex
Me1 to Me0
 
anti-H3K4me0-K
 
HMT
MLL1/MLL4 complex
Me0 to Me2
 
anti-H3K4me0-K
 
HMT
SMYD2
Me0 to Me2
 
anti-H3K4me2-K
 
HDM
KDM5A
Me3 to Me2
 
anti-H3K4me1-K
anti-H3K4me2-K
H3K9
HMT
G9a
Me0 to Me2
 
anti-H3K9me2-K
 
HMT
G9a
Me1 to Me2
 
anti-H3K9me2-K
 
HMT
SUV39h1
Me0 to Me3
Me1 to Me3
anti-H3K9me3-K
 
HDM
JMJD2C/KDM4C
Me3 to Me2
 
anti-H3K9me2-K
 
HMT
KDM3B
Me1 to Me0
Me1 to Me0
anti-H3K9me0-K
 
更多....

HTRF products for Cellular Assays

Histone Modification Location
Reactions
Lysis Buffer
HTRF Antibody Pair
H3K27
H3K27 me2
HTRF Epi Lysis buffer
anti-H3K27me2-d2
anti-H3-K (N-term)
H3K27 me3
HTRF Epi Lysis buffer
anti-H3K27me3-d2
anti-H3-K (N-term)
H3K36
H3K36 me2
HTRF Epi Lysis buffer
anti-H3K36me2-d2
anti-H3-K (N-term)
Total H3
H3
HTRF Epi Lysis buffer
Anti-H3-K

 
  如想了解更多,请联系上海优宁维生物科技有限公司(www.univ-bio.com)

上海:021-38015269/89/99 info@univ-bio.com 北京:010-62974534/1441/4210 beijing@univ-bio.com
广州:020-38036121/07 guangzhou@univ-bio.com 天津:022-58288668 tianjin@univ-bio.com

湖北/湖南:027-83342136

wuhan@univ-bio.com 南京/安徽:025-83728850 nanjing@univ-bio.com
杭州:0571-89715026 hangzhou@univ-bio.com 苏州:0512-65923356 sz1688@univ-bio.com
济南:0531-55571091 jinan@univ-bio.com 沈阳:024-31282791 shenyang@univ-bio.com
       
 

免费服务电话:4008-168-068 Email:info@univ-bio.com

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